Theranostic Somatostatin Receptor Ligands

The currently used theranostic pairs such as [68Ga]Ga-DOTA-TATE and [177Lu]Lu DOTA-TATE have different chemical and pharmacological properties due to the different metals incorporated, which has increased the interest in "true theranostic compounds" where one compound can be labeled with a diagnostic and therapeutic radionuclide with the same pharmacological properties. In addition, a shift from Ga-68- to F-18-labeled compounds has occurred in recent years.

With the development of the new SiFA building block (SiFA)SeFe, a silicon-based fluoride acceptor is now available for the first time that provides sufficient hydrophilicity directly to the aromatic through the use of a carboxylate group in one meta-position and an amide group in the other meta-position to the Si function. The innovative radiohybrids that can be labeled with fluorine-18 (F-18) for precise diagnostic purposes and lutetium-177 (Lu-177) for effective therapeutic applications.